Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Původní práce / Original papers

ACTA CHIRURGIAE ORTHOPAEDICAE ET TRAUMATOLOGIAE ČECHOSL.,
73, 2006, p. 373

Léčba hlubokých chondrálních defektů pately transplantací kultivovaných autologních chondrocytů

Therapy of Severe Chondral Defects of the Patella by Autologous Chondrocyte Implatation

M. HANDL1, T. TRČ1, M. HANUŠ1, E. ŠŤASTNÝ1, M. FRICOVÁ-POULOVÁ2, J. NEUWIRTH2, J. ADLER3, D. HAVRANOVÁ3, F. VARGA4
1 Ortopedická klinika dětí a dospělých 2.LF UK a FN Motol, Praha
2 Klinika zobrazovacích metod, 2.LF UK a FN Motol, Praha
3 Tkáňová banka, FN Brno-Bohunice
4 Oddělení biofyziky 2. LF UK a FN Motol, Praha
ABSTRACT

PURPOSE OF THE STUDY
The aim of this study was to present the results of treatment of deep chondral defects of the patella by transplantation of a solid chondral graft formed by autologous cultured chondrocytes.

MATERIAL AND METHODS
Indications for autologous chondrocyte implantation most frequently included acute trauma to the knee, particularly the patella, which resulted in a severe focal cartilage defect. The lesions were assessed on the basis of the Bessette and Hun-ter classification preoperatively, and on the Outerbridge classification during arthroscopy. A sample of healthy cartilage was harvested from a non-weight-bearing area of the trochlea femoris. After cultivation of chondrocytes for 28 to 42 days in the tissue bank, a solid chondral graft, prepared with the use of fibrin glue (Tissucol), was ready for implantation.

RESULTS
Six patients, two males and four females (average age, 21.1 years; range, 13 to 39 years) were treated by this method in the period from July 2003 to October 2005. Follow-up ranged from 1 to 25 months, with an average of 18.5 months. The patients were examined postoperatively by magnetic resonance imaging (MRI) at 2 weeks, 2 and 6 months, and at 1 year. The clinical results were evaluated by the Meyers, the Tegner and the Lysholm knee scoring systems. Two of the six patients, in whom the follow-up period was shorter than 6 months, were not included in the evaluation.

CONCLUSIONS
A significant improvement in knee function was recorded when the preoperative and finál follow-up stages were com-pared, as well as on comparison with the healthy contralateral knee joint. MRI examination showed good graft incorporation in all patients.

Key words: patella, chondrocytes, cartilage transplantation.

Celá stať v dokumentu PDF

Zpět


Nabídka nakladatelství:

 

Peter Wendsche, Radek Veselý et al.
Úskalí a komplikace při léčení zlomenin

Úskalí a komplikace při léčení zlomenin

 

Petr Chládek
Femoroacetabulární impingement syndrom

Femoroacetabulární impingement syndrom

 

Ctibor Povýšil
Patomorfologie chorob kostí a kloubů

Patomorfologie chorob kostí a kloubů