Acta Chir Orthop Traumatol Cech. 1998; 65(1):24-30
[Dynamics of antibiotic release from glass ceramic material.].
- Ustav a katedra klinické mikrobiologie FN, Hradec Králové
Using the agar pit method, the authors assessed elution curves of the antibiotics lincomycin, gentamicin and neomycin previously used to saturate bioactive glass ceramic materials BAS-0 and BAS-HA with different porosities. The release into buffered saline at a temperature of 37 C was investigated for a 60-day period. Coagulated human blood on the surface of the granules and blocks used retarded and prolonged the release of antibiotics from glass ceramics. Elution took place in two stages: during the first 12 hours, the maximum of each antibiotic was released and this rapid rise was followed by flattening of the curve and release of a small amount of antibiotic only, which however was detectable still after 60 days. From BAS-0 lincomycin was released most readily, from BAS-HA gentamicin. The poorest release was recorded in all instances from neomycin, al-though the amount of this antibiotic was sufficient for bactericide activity. Further research should lead to prolongation of the first stage of maximum antibiotic release. Key words: bioactive, porous glass ceramics, release of antibiotics from carrier.
Published: January 1, 1998 Show citation