Acta Chir Orthop Traumatol Cech. 2006; 73(1):39-44 | DOI: 10.55095/achot2006/007

Peripheral Primitive Neuroectodermal Tumor - PNETCase report

J. KOUDELOVÁ1, M. KUNE©OVÁ1, K. KOUDELA, Jr.2, J. MATĚJKA2, P. NOVÁK3, J. PRAUSOVÁ4
1 Radiodiagnostická klinika LF UK a FN, Plzeň
2 Klinika ortopedie a traumatologie pohybového ústrojí LF UK a FN, Plzeň
3 Chirurgická klinika LF UK a FN, Plzeň
4 Radioterapeuticko-onkologické oddělení FN Motol, Praha

The authors describe three cases of peripheral primitive neuroectodermal tumor. The tumor was found in soft tissues of the crus, shoulder girdle and perineum, and was also located paravertebrally and epidurally at the level of L1-L2 vertebrae. Radiological findings were not specific for this disease. The results of imaging methods (sonography, CT, MRI, DSA) were important for the assessment of tumor size, its boundary and invasion of the surrounding tissues, and for the evaluation of tumor response to therapy and detection of recurrent disease. The PNET diagnosis was based on immunohistochemical, biochemical and cytogenetic examinations. One patient died 5 months after the first clinical signs were manifested; the two patients surviving for 2 and 1 3/4 years after first sign manifestation, respectively, remained in the care of cancer specialists.

Keywords: skeletal Ewing's sarcoma, extra-skeletal Ewing's sarcoma, Ewing's sarcoma family of tumors, peripheral primitive neuroectodermal tumor

Published: February 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
KOUDELOVÁ J, KUNE©OVÁ M, KOUDELA K, MATĚJKA J, NOVÁK P, PRAUSOVÁ J. Peripheral Primitive Neuroectodermal Tumor - PNET. Acta Chir Orthop Traumatol Cech. 2006;73(1):39-44. doi: 10.55095/achot2006/007. PubMed PMID: 16613747.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. ANGERVALL, L., ENZINGER, F. M.: Extraskeletal neoplasm resembling Ewing's sarcoma. Cancer, 36:240-251, 1975. Go to original source...
    2. GOSTOUT, B. S., LINDOR, N. M., DiMARCO, C. S., PEETHAMBARAM, P. P., CLAYTON, A. C.: Pelvic primitive neuroectodermal tumor associated with a cluster of small round cell tumor: case report and review of current literature. Gynecol. Oncol., 91: 247-253, 2003. Go to original source... Go to PubMed...
    3. DELATTRE, O., ZUCMAN, J., MELOT, T., GARAU, S. X., ZUCKER, J. M., LENOIR, G. M., AMBROS, P. F., SHEER, D., TURC-CAREL, C., TRICHE, T. J., AURIAS, A., THOMAS, G.: The Ewing Family of Tumors - A Subgroup of Small Round - Cell Tumors Defined by Specific Chimeric Transcripts. New Engl. J. Med., 331:294-299, 1994. Go to original source... Go to PubMed...
    4. EWING, J.: Diffuse endothelioma of bone. Proc. N. Y. path. Soc., 21:17-24, 1921.
    5. FAUBERT, C., INNIGER, R.: MRI and pathological findings in two cases of Askin tumors. Neuroradiology, 33:277-281, 1991. Go to original source... Go to PubMed...
    6. GAONA-LUVIANO, P., UNDA-FRANCO, E., GONZALEZ-JARA, L., ROMERO, P., MEDINA-FRANCO, H.: Primitive neuroectodermal tumor of the vagina. Gynecol. Oncol., 91:456-458, 2003. Go to original source... Go to PubMed...
    7. HINDMAN, B. W., GILL, H. K., ZUPPAN, C. W.: Primitive neuroectodermal tumor in a child with tuberous sclerosis. Skeletal Radiol., 26:184-187, 1997. Go to original source... Go to PubMed...
    8. CHOW, E., MERCHANT, T. E., PAPPO, A., JENKINS, J. J., SHAH, A. B., KUN, L. E.: Cutaneous and subcutaneous Ewing's sarcoma an indolent disease. Int. J. Radiat. Oncol. Biol. Phys., Vol. 46:433-438, 2000. Go to original source...
    9. JI HOON SHIN, HO KYU LEE, SEUNG CHUL RHIM, KYUNG-JA CHO, CHOONG GON CHOI, DAE CHUL SUH.: Spinal Epidural Extraskeletal Ewing Sarcoma: MR Findings in Two Cases. Amer. J Neuroradiol., 22:795-798, 2001.
    10. KOJIMA, T., ASAMI, S., CHIN, M., YOSHIDA, Y., MUGISHIMA, H., SUZUKI,T.: Detection of chimeric genes in Ewing's sarcoma and its clinic applications. Biol. Pharm. Bull., 25:991-994, 2002. Go to original source... Go to PubMed...
    11. KOUDELA, K.: Ortopedie. Praha, Karolinum 2004.
    12. MATĚJOVSKÝ, Z., POVÝ©IL, C., KOLÁŘ, J.: Kostní nádory. Praha, Avicenum 1988.
    13. MORITAKE, H., SUGIMOTO, T., KURODA, H., HIDAKA, F., TAKAHASHI, Y., TSUNEYOSHI, M., MITSUAKI, A., YOSHIDA, M. A., CUI, Q., AKIYSHI, K., IZUMI, T., NUNOI, H.: Newly established Askin tumor cell line and overexpression of focal adhesion kinase in Ewing sarcoma family of tumors cell lines. Cancer Genetics and Cytogenetics, 146:102-109, 2003. Go to original source... Go to PubMed...
    14. O'KEEFFE, F., LORIGAN, J. G, WALLACE, S.: Radiological features of extraskeletal Ewing sarcoma. Brit. J. Radiol., 63:456-460, 1990. Go to original source... Go to PubMed...
    15. PETER, M., GILBERT, E., DELATTRE, O.: A Multiplex Real - Time PCR Assay for the Detection of Gene Fusions Observed in Solid Tumors. Laboratory Investigation, 81:905-912, 2001. Go to original source... Go to PubMed...
    16. RESNICK, D., KRANSDORF, M. J.: Bone and Joint imaging. Philadelphia, Elsevier Saunders 2005.
    17. ROSE, J. S., HERMANN, G., MENDELSON, D. S., AMBINDER, E. P.: Extraskeletal Ewing sarcoma with computed tomography correlation. Skeletal Radiol., 9:234-237, 1983. Go to original source... Go to PubMed...
    18. SALLUSTIO, G., PIRRONTI, T., LASORELLA, A., NATALE, L., BRAY, A.,MARANO, P.: Diagnostic imaging of primitive neuroectodermal tumour of the chest wall (Askin tumour). Pediat. Radiol., 28:697-702, 1998. Go to original source... Go to PubMed...
    19. SCHULMAN, H., NEWMAN-HEINMAN, N., KURTZBART, E., MAOR, E., ZIRKIN, H., LAUFER,L.: Thoracoabdominal peripheral primitive neuroectodermal tumors in childhood: radiological features. Europ. Radiol., 10:1649-1652, 2000. Go to original source... Go to PubMed...
    20. TATEISHI, U., GLADISH, G. W., KUSUMOTO, M., HASEGAWA, T., YOKOYAMA, R., T SUCHIYA, R., MORIYAMA, N.: Chest wall tumors: radiologic findings and pathologic correlation. Part 2: Malignant tumors. Radiographics, 23:1491-1508, 2003. Go to original source... Go to PubMed...
    21. YOSHINO, N., KOJIMA, T., ASAMI, S., MOTOHASHI, S., YOSHIKAZU, Y., CHIN, M., SHICHINO, H., YOSHIDA, Y., NEMOTO, N., KANEKO, M., MUSGISHIMA, H., SUZUKI, T.: Diagnostic Significance and Clinical Applications of Chimeric Genes in Ewing's Sarcoma. Biol. Pharm. Bull., 26: 585-588, 2003. Go to original source... Go to PubMed...

    Return to the content