Acta Chir Orthop Traumatol Cech. 2013; 80(4):278-283 | DOI: 10.55095/achot2013/046

Platelet-Rich Plasma Injection Is More Effective than Hyaluronic Acid in the Treatment of Knee OsteoarthritisOriginal papers

F. Say1,*, D. Gürler2, K. Yener2, M. Bülbül3, M. Malkoç3
1 Department of Orthopaedics and Traumatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
2 Department of Orthopaedics and Traumatology, Samsun Training and Research Hospital, Samsun, Turkey
3 Department of Orthopaedics and Traumatology, Faculty of Medicine, Medipol University, Istanbul, Turkey

Purpose of the study
There is increasing use of platelet-rich plasma (PRP) in orthopaedics as it is a simple, cheap and minimally invasive technique. This study aimed to compare the effects of the use of PRP and hyaluronic acid (HA) injections in the knee of patients diagnosed with and being followed-up for degenerative arthritis.
Materials and Methods
This prospective study included 90 patients with complaints of knee pain with findings of mild or moderate degenerative arthritis. In the PRP group (n = 45), one intra-articular injection was applied and in the HA group (n = 45), three doses of intra-articular injection were applied. Clinical evaluation was made by Knee Injury and Osteoarthritis Outcome Score (KOOS) and a visual pain scale.
Results
No severe adverse events was observed. Statistically significant better results in the KOOS score and visual pain scale was determined in PRP group than HA group at 3 months and 6 months follow up. The cost of the application for the PRP group was lower than that of the HA group.
Conclusion
The results of this study have shown the application of single dose PRP to be a safe, effective and low-cost method for treating OA. However, further studies are required for a more clear result.

Keywords: platelet-rich plasma, hyaluronic acid, knee osteoarthritis, growth factors

Published: August 1, 2013  Show citation

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Say F, Gürler D, Yener K, Bülbül M, Malkoç M. Platelet-Rich Plasma Injection Is More Effective than Hyaluronic Acid in the Treatment of Knee Osteoarthritis. Acta Chir Orthop Traumatol Cech. 2013;80(4):278-283. doi: 10.55095/achot2013/046. PubMed PMID: 24119476.
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