Acta Chir Orthop Traumatol Cech. 2014; 81(1):9-21 | DOI: 10.55095/achot2014/001

Lower Limb Salvage: Indication and Decision Making for Replantation, Revascularisation and AmputationCurrent concepts review

S. Märdian*, K. D. Schaser, F. Wichlas, C. Jakobs, B. Kraphol, P. Schwabe
Charité - Universitätsmedizin Berlin, CMSC - Center of musculosceletal surgery, Berlin, Germany

Defining reproducible criteria for lower extremity salvage following severe high-energy trauma continues to be one of the most challenging and controversially discussed fields in orthopaedic surgery. At present, however, the difficult performance, limited availability and number of valid reconstructive options for complex injury types, i. e. simultaneous osteoligamentous trauma with neurovascular lesions and severe soft tissue defects ("composite/compound multilayer defects") represent the decisive prognostic injury components triggering and determining the fate of the limb. Consequently, due to the complex injury pattern of the extremity and the overall situation of multiple injured patient the treatment and decision making has to be made in a priority-adapted algorithm. In this treatment algorithm interdisciplinary cooperation with vascular and plastic surgeons is of tremendous importance. Although the number of severely injured patients remains stable in the last decade, changes in the treatment algorithms result from increased survival rates of multiple injured patients and improved modern reconstructive options leading to continuously increasing rates of salvaged limbs. This paper aimed to systematically review the current literature for lower extremity injuries in order to unravel the different surgical treatment options and provide guidelines for decision making with corresponding treatment algorithms for limb salvage. Furthermore, the experiences in the management of mangled extremities in our centre are presented and illustrated/underscored with different cases.

Published: February 1, 2014  Show citation

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Märdian S, Schaser KD, Wichlas F, Jakobs C, Kraphol B, Schwabe P. Lower Limb Salvage: Indication and Decision Making for Replantation, Revascularisation and Amputation. Acta Chir Orthop Traumatol Cech. 2014;81(1):9-21. doi: 10.55095/achot2014/001. PubMed PMID: 24755062.
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References

  1. Akimitsu, T., Gute, D. C., Korthuis, R. J.: Leukocyte adhesion induced by inhibition of nitric oxide production in skeletal muscle. J. Appl. Physiol., 78: 1725-1732, 1995. Go to original source... Go to PubMed...
  2. Biemer, E.: [Classification of total and subtotal amputations]. Handchirurgie, 9: 21-23, 1977.
  3. Biemer, E.: Definitions and classifications in replantation surgery. Br. J. Plast. Surg., 33: 164-168, 1980. Go to original source... Go to PubMed...
  4. Blick, S. S., et al.: Compartment syndrome in open tibial fractures. J. Bone Jt Surg., 68-A: 1348-1353, 1986. Go to original source...
  5. Bosse, M. J., et al.: A prospective evaluation of the clinical utility of the lower-extremity injury-severity scores. J. Bone Jt Surg., 83-A: 3-14, 2001. Go to original source... Go to PubMed...
  6. Bosse, M. J., et al.: An analysis of outcomes of reconstruction or amputation after leg-threatening injuries. N. Engl. J. Med., 347: 1924-1931, 2002. Go to original source... Go to PubMed...
  7. Brumback, R. J., Jones, A. L.: Interobserver agreement in the classification of open fractures of the tibia. The results of a survey of two hundred and forty-five orthopaedic surgeons. J. Bone Jt Surg., 76-A: 1162-1166 1994. Go to original source... Go to PubMed...
  8. Busquets, A. R., et al.: Helical computed tomographic angiography for the diagnosis of traumatic arterial injuries of the extremities. J. Trauma, 56: 625-628, 2004. Go to original source... Go to PubMed...
  9. Caudle, R. J., Stern, P. J.: Severe open fractures of the tibia. J. Bone Jt Surg., 69-A: 801-807, 1987. Go to original source...
  10. Chan, P. S., et al.: Compartment syndrome after isolated perfusion of the leg: a case report. Am. J. Orthop. (Belle Mead NJ), 26: 369-370, 1997.
  11. Court-Brown, C. M., et al.: The epidemiology of open fractures in adults. A 15-year review. Injury, 43: 891-897, 2012. Go to original source... Go to PubMed...
  12. Court-Brown, C. M., et al.: The epidemiology of open long bone fractures. Injury, 29: 529-534, 1998. Go to original source... Go to PubMed...
  13. Dagum, A. B., et al.: Salvage after severe lower-extremity trauma: are the outcomes worth the means? Plast. Reconstr. Surg., 103: 1212-1220, 1999. Go to original source...
  14. Doukas, W. C.: The Military Extremity Trauma Association/limb salvage (METALS) study: Comparing outcomes for amputation versus limb salvage following major lower extremity trauma. Presented at the 2010 Annual Meeting of the Orthopaedic Trauma Association, Baltimore, Oct. 13-16 2010.
  15. Elliott, K. G., Johnstone, A. J.: Diagnosing acute compartment syndrome. J. Bone Jt Surg., 85-B: 625-632, 2003. Go to original source...
  16. Fairhurst, M. J.: The function of below-knee amputee versus the patient with salvaged grade III tibial fracture. Clin. Orthop. Relat. Res., 301: 227-232, 1994. Go to original source...
  17. Filippin, L. I., et al.: Nitric oxide and repair of skeletal muscle injury. Nitric Oxide, 21: 157-163, 2009. Go to original source... Go to PubMed...
  18. Foster, B. R., et al.: Integration of 64-detector lower extremity CT angiography into whole-body trauma imaging: feasibility and early experience. Radiology, 261: 787-795, 2011. Go to original source... Go to PubMed...
  19. Francel, T. J.: Improving reemployment rates after limb salvage of acute severe tibial fractures by microvascular soft-tissue reconstruction. Plast. Reconstr. Surg., 93: 1028-1034, 1994. Go to original source... Go to PubMed...
  20. Francel, T. J., et al.: Microvascular soft-tissue transplantation for reconstruction of acute open tibial fractures: timing of coverage and long-term functional results. Plast. Reconstr. Surg., 89: 478-487; discussion 488-489, 1992. Go to original source...
  21. Gakhal, M. S., Sartip, K. A.: CT angiography signs of lower extremity vascular trauma. AJR Am. J. Roentgenol., 193: W49-57, 2009. Go to original source... Go to PubMed...
  22. Georgiadis, G. M., et al.: Open tibial fractures with severe soft-tissue loss. Limb salvage compared with below-the-knee amputation. J. Bone Jt Surg., 75-A: 1431-1441, 1993. Go to original source... Go to PubMed...
  23. Geyer, L. L., et al.: Polytrauma: optimal imaging and evaluation algorithm. Semin. Musculoskelet. Radiol., 17: 371-379, 2013. Go to original source... Go to PubMed...
  24. Godina, M.: Early microsurgical reconstruction of complex trauma of the extremities. Plast. Reconstr. Surg., 78: 285-292, 1986. Go to original source... Go to PubMed...
  25. Gupta, A., et al.: Treatment of the severely injured upper extremity. Instr. Course Lect., 49: 377-396, 2000.
  26. Gustilo, R. B., Anderson, J. T.: Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J. Bone Jt Surg., 58-A: 453-458, 1976. Go to original source...
  27. Gustilo, R. B., Gruninger, R. P., Davis, T.: Classification of type III (severe) open fractures relative to treatment and results. Orthopedics, 10: 1781-1788, 1987.
  28. Hansen, S. T., Jr.: The type-IIIC tibial fracture. Salvage or amputation. J. Bone Jt Surg., 69-A: 799-800, 1987. Go to original source...
  29. Hildebrand, F., et al.: Damage control: extremities. Injury, 35: 678-689, 2004. Go to original source... Go to PubMed...
  30. Horn, B. D., Rettig, M. E.: Interobserver reliability in the Gustilo and Anderson classification of open fractures. J. Orthop. Trauma, 7: 357-360, 1993. Go to original source... Go to PubMed...
  31. Kline, D. G., Hackett, E. R.: Reappraisal of timing for exploration of civilian peripheral nerve injuries. Surgery, 78: 54-65, 1975.
  32. Kostler, W., P. C. Strohm,P. C., Sudkamp, N. P.: Acute compartment syndrome of the limb. Injury, 36: 992-998, 2005. Go to original source... Go to PubMed...
  33. Krettek, C.: [Fracture and soft tissue damage]. Chirurg, 69: 684-700, 1998. Go to original source... Go to PubMed...
  34. Kuzniec, S., et al.: Diagnosis of limbs and neck arterial trauma using duplex ultrasonography. Cardiovasc. Surg., 6: 358-366, 1998. Go to original source... Go to PubMed...
  35. Lange, R. H.: Limb reconstruction versus amputation decision making in massive lower extremity trauma. Clin. Orthop. Relat. Res., 243: 92-99, 1989. Go to original source...
  36. Lausevic, Z., et al.: Predicting multiple organ failure in patients with severe trauma. Can. J. Surg., 51: 97-102, 2008.
  37. Lenz, A., G. A. Franklin, g. A., Cheadle, W. G.: Systemic inflammation after trauma. Injury, 38: 1336-1345, 2007. Go to original source... Go to PubMed...
  38. Lundborg, G., Rydevik, B.: Effects of stretching the tibial nerve of the rabbit. A preliminary study of the intraneural circulation and the barrier function of the perineurium. J. Bone Jt Surg., 55-B: 390-401, 1973. Go to original source...
  39. Markgraf, E.: [Traumatic peripheral vascular injuries]. Unfallchirurg, 101: 507, 1998. Go to original source...
  40. McQueen, M. M., Court-Brown, C. M.: Compartment monitoring in tibial fractures. The pressure threshold for decompression. J. Bone Jt Surg., 78-B: 99-104, 1996. Go to original source...
  41. Menger, M. D., Vollmar, B.: Surgical trauma: hyperinflammation versus immunosuppression? Langenbecks Arch. Surg., 389: 475-484, 2004. Go to original source... Go to PubMed...
  42. Miller, H. H., Welch, C. S.:Quantitative studies on the time factor in arterial injuries. Ann. Surg., 130: 428-438, 1949. Go to original source...
  43. Mubarak, S. J., Owen, C. A.: Double-incision fasciotomy of the leg for decompression in compartment syndromes. J. Bone Jt Surg., 59-A: 184-187, 1977. Go to original source...
  44. Owings, M. F., Kozak, L. J.: Ambulatory and inpatient procedures in the United States, 1996. Vital. Health Stat., 13: 1-119, 1998.
  45. Pallister, I., Empson, K.: The effects of surgical fracture fixation on the systemic inflammatory response to major trauma. J. Am. Acad. Orthop. Surg., 13: p. 93-100, 2005. Go to original source... Go to PubMed...
  46. Panetta, T. F., et al.: Duplex ultrasonography versus arteriography in the diagnosis of arterial injury: an experimental study. J. Trauma, 33: 627-635; discussion 635-636, 1992. Go to original source... Go to PubMed...
  47. Parrett, B. M., et al.: Lower extremity trauma: trends in the management of soft-tissue reconstruction of open tibia-fibula fractures. Plast. Reconstr. Surg., 117: 1315-1322; discussion 1323-1324, 2006. Go to original source... Go to PubMed...
  48. Patzakis, M. J., et al.: Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. J. Orthop. Trauma, 14: 529-533, 2000. Go to original source... Go to PubMed...
  49. Patzakis, M. J., Wilkins, J.: Factors influencing infection rate in open fracture wounds. Clin. Orthop. Relat. Res., 243: 36-40, 1989. Go to original source...
  50. Pieroni, S., et al.: Use of 64-row multidetector CT angiography in blunt and penetrating trauma of the upper and lower extremities. Radiographics, 29: 863-876, 2009. Go to original source... Go to PubMed...
  51. Roberts, C. S., et al.: Damage control orthopaedics: evolving concepts in the treatment of patients who have sustained orthopaedic trauma. Instr. Course Lect., 54: 447-462, 2005. Go to original source...
  52. Rosenfield, J., Paksima, N.: Peripheral nerve injuries and repair in the upper extremity. Bull. Hosp. Jt Dis., 60: 155-161, 2001.
  53. Rubinstein, I., et al.: Involvement of nitric oxide system in experimental muscle crush injury. J. Clin. Invest., 101: 1325-1333, 1998. Go to original source... Go to PubMed...
  54. Schaser, K. D., et al.: [The multidisciplinary approach to reconstructive surgery of the extremities-considerations for trauma and orthopedic surgery]. Chirurg, 75: 399-410, 2004. Go to original source... Go to PubMed...
  55. Schaser, K. D., et al.: [Interdisciplinarity in reconstructive surgery of the extremities]. Unfallchirurg, 107: 732-743, 2004. Go to original source... Go to PubMed...
  56. Schaser, K. D., et al.: In vivo imaging of human pancreatic microcirculation and pancreatic tissue injury in clinical pancreas transplantation. Am. J. Transplant., 5: 341-350, 2005. Go to original source... Go to PubMed...
  57. Schaser, K. D., et al.: In vivo analysis of microcirculation following closed soft-tissue injury. J. Orthop. Res., 17: 678-685, 1999. Go to original source...
  58. Schwabe, P., Haas, N. P., Schaser, K. D.: [Fractures of the extremities with severe open soft tissue damage. Initial management and reconstructive treatment strategies]. Unfallchirurg, 113: 647-670; quiz 671-672, 2010. Go to original source... Go to PubMed...
  59. Smail, N., et al.: Role of systemic inflammatory response syndrome and infection in the occurrence of early multiple organ dysfunction syndrome following severe trauma. Intensive Care Med., 21: 813-816, 1995. Go to original source... Go to PubMed...
  60. Tidball, J. G.: Inflammatory processes in muscle injury and repair. Am. J. Physiol. Regul. Integr. Comp. Physiol., 288: R345-353, 2005. Go to original source... Go to PubMed...
  61. Tscherne, H., Oestern, H. J.: [A new classification of soft-tissue damage in open and closed fractures (author's transl.)]. Unfallheilkunde, 85: 111-115, 1982.
  62. Whitesides, T. E., Heckman, M. M.: Acute compartment syndrome: Update on diagnosis and treatment. J. Am. Acad. Orthop. Surg., 4: 209-218, 1996. Go to original source... Go to PubMed...
  63. Yazar, S., Lin, C. H., Wei, F. C.: One-stage reconstruction of composite bone and soft-tissue defects in traumatic lower extremities. Plast. Reconstr. Surg., 114: 1457-1466, 2004. Go to original source... Go to PubMed...
  64. Young, L., Wray, R. C., Weeks, P. M.: A randomized prospective comparison of fascicular and epineural digital nerve repairs. Plast. Reconstr. Surg., 68: 89-93, 1981. Go to original source... Go to PubMed...
  65. Zalavras, C. G., et al.: Management of open fractures and subsequent complications. Instr. Course Lect., 57: 51-63, 2008.
  66. Ziegler-Graham, K., et al.: Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch. Phys. Med. Rehabil., 89: 422-429, 2008. Go to original source... Go to PubMed...