Acta Chir Orthop Traumatol Cech. 2020; 87(1):9-16 | DOI: 10.55095/achot2020/001

Creatine Kinase and Myoglobin Levels as Indicators of Perioperative Muscle Damage during Open- and Mini-Invasive Stabilization of Thoracic and Lumbar Spine Fracture - a Prospective Randomized StudyOriginal papers

T. MATĚJKA1,*, J. ZEMAN1, J. BELATKA1, Z. KLÉZL2, J. RACEK3, J. MATĚJKA1
1 Department of Orthopaedics and Locomotive Apparatus Traumatology of the Faculty of Medicine in Pilsen, Charles University, Czech Republic
2 University Hospitals Derby and Burton NHS Foundation Trust, United Kingdom
3 Department of Clinical Biochemistry and Haematology of the Faculty of Medicine in Pilsen, Charles University, Czech Republic

PURPOSE OF THE STUDY:
In this randomized prospective study, we monitored and compared perioperative changes in skeletal muscle enzymes blood levels in open and mini-invasive stabilization of thoracolumbar spine fractures. The established hypothesis was to confirm higher blood levels of muscle enzymes in open stabilization.

MATERIAL AND METHODS:
This study included 38 patients with the mean age of 46.4 years. 19 injuries were managed in an open procedure and 19 procedures were mini-invasive. Venous blood was taken intermittently at short intervals to determine the levels of skeletal muscle enzymes. The catalytic concentration of creatine kinase was determined via an enzymatic UV-test, and the concentration of myoglobin via electro-chemiluminescent immunoassay. Enzyme levels were processed statistically. The Wilcoxon test was used.

RESULTS:
The median increase in the values of both enzymes is higher in the mini-invasive method than in the open method in both the surgery phase for the injury and in the extraction phase. The median increase in the values of both enzymes is higher in both methods for the primary procedure phase compared to the extraction phase. All results are statistically significant at p of

Keywords: creatine kinase, myoglobin, muscle enzymes, spine fracture, spine surgery, miniinvasive surgery

Published: December 1, 2020  Show citation

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MATĚJKA T, ZEMAN J, BELATKA J, KLÉZL Z, RACEK J, MATĚJKA J. Creatine Kinase and Myoglobin Levels as Indicators of Perioperative Muscle Damage during Open- and Mini-Invasive Stabilization of Thoracic and Lumbar Spine Fracture - a Prospective Randomized Study. Acta Chir Orthop Traumatol Cech. 2020;87(1):9-16. doi: 10.55095/achot2020/001. PubMed PMID: 32131965.
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