Acta Chir Orthop Traumatol Cech. 2024; 91(4):245-247 | DOI: 10.55095/achot2024/033

Neurogenic Heterotopic Ossification of the Hip: a Case Report

M. ÇELIK1, S. H. BAªARAN2
1 Sadi Konuk Training and Research Hospital, Department of Orthopedics and Traumatology, Bakirköy/Istanbul, Turkey
2 University of Health Sciences, Bakirköy Dr. Sadi Konuk Training and Research Hospital, Department of Orthopedics and Traumatology, Bakirköy/Istanbul, Turkey

Heterotopic ossification (HO) denotes aberrant osteogenesis in extra-skeletal tissues, often associated with neurological disorders, total hip arthroplasty, and specific traumatic scenarios. Neurogenic heterotopic ossification manifests prominently subsequent to traumatic brain injury or spinal cord injury, with Guillain-Barre Syndrome presenting an infrequent etiological link. This article details the case of a 56-year-old female diagnosed with Guillain-Barre Syndrome, who developed neurogenic heterotopic ossification around both hips within two years of disease onset. The patient's medical history included mechanical ventilation, incomplete tetraplegia, and prolonged immobilization. A conclusive diagnosis of HO was established through radiological and clinical assessments. After neurogenic heterotopic ossification was confirmed, the patient had surgery to remove the lesions, radiation therapy, and medication treatments as planned. Physical therapy was introduced one week post-surgery, with subsequent follow-ups tracking improvements in pain levels, range of motion (ROM), and Activities of Daily Living scores.

Keywords: neurogenic heterotopic ossification, Guillain-Barre syndrome, hip, excision.

Received: May 9, 2024; Revised: May 9, 2024; Accepted: July 13, 2024; Published: September 13, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
ÇELIK M, BAªARAN SH. Neurogenic Heterotopic Ossification of the Hip: a Case Report. Acta Chir Orthop Traumatol Cech. 2024;91(4):245-247. doi: 10.55095/achot2024/033. PubMed PMID: 39342647.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Kerdoncuff V, Sauleau P, Petrilli S, Duruflé A, Ben Beroukh K, Brissot R, Gallien P. Paraostéoarthropathies dans le syndrome de Guillain-Barré [Heterotopic ossification in Guillain-Barré syndrome]. Ann Readapt Med Phys. 2002;45:198-203. French. doi: 10.1016/s0168-6054(02)00203-9. Go to original source... Go to PubMed...
    2. Taly AB, Nair KP, Jayakumar PN, Ravishankar D, Kalaivani PL, Indiradevi B, Murali T. Neurogenic heterotopic ossification: a diagnostic and therapeutic challenge in neurorehabilitation. Neurol India. 2001;49:37-40.
    3. Zeilig G, Weingarten HP, Levy R, Peer I, Ohry A, Blumen N. Heterotopic ossification in Guillain-Barré syndrome: incidence and effects on functional outcome with long-term follow-up. Arch Phys Med Rehabil. 2006;87:92-95. doi: 10.1016/j.apmr.2005.07.308. Go to original source... Go to PubMed...
    4. Chauveau C, Devedjian JC, Blary MC, Delecourt C, Hardouin P, Jeanfils J, Broux O. Gene expression in human osteoblastic cells from normal and heterotopic ossification. Exp Mol Pathol. 2004;76(1):37-43. doi: 10.1016/j.yexmp.2003.10.001. Go to original source... Go to PubMed...
    5. de l'Escalopier N, Salga M, Gatin L, Genêt F, Denormandie P. Resection of heterotopic ossification around the hip after trauma. EFORT Open Rev. 2019;4:263-268. doi: 10.1302/2058-5241.4.180098. Go to original source... Go to PubMed...
    6. Debre J, ©tìpán Z, Dupal J. Kyselina tranexamová sni¾uje výskyt heterotopických osifikací po primární elektivní TEP kyèelního kloubu [Tranexamic Acid Reduces the Incidence of Heterotopic Ossifications after Elective Primary Total Hip Arthroplasty]. Acta Chir Orthop Traumatol Cech. 2021;88:13-17. Go to original source...
    7. George DH, Scheithauer BW, Spinner RJ, Buchler U, Cronin TE, Reedy MT, Arndt BC. Heterotopic ossification of peripheral nerves ("neuritis ossificans"): report of two cases. Neurosurgery. 2002;51:244-246. doi: 10.1097/00006123-200207000-00039. Go to original source... Go to PubMed...
    8. Ploumis A., Varvarousis D., Theodorou A., Gelalis I., Korompilias A., and Pakos E. Heterotopic ossification (HO) as a complication of Guillain-Barre syndrome (GBS): a case report. Phys Med Rehabil Res, 2018;3:1-3. Go to original source...
    9. Sivakumaran D, Pathinathan K, Danisious J, Thayasivam G. Myositis ossificans of the hip joint causing sciatic nerve palsy following Guillain-Barré syndrome: a case report. Int J Surg Case Rep. 2021;84:106110. doi: 10.1016/j.ijscr.2021.106110. Go to original source... Go to PubMed...
    10. Cipriano C, Pill SG, Rosenstock J, Keenan MA. Radiation therapy for preventing the recurrence of neurogenic heterotopic ossification. Orthopedics. 2009;32:orthosupersite.com/view.asp?rID= 42854. doi: 10.3928/01477447-20090728-33. Go to original source... Go to PubMed...

    Return to the content