Acta Chir Orthop Traumatol Cech. 2022; 89(4):286-292 | DOI: 10.55095/achot2022/046

Comparison of Intravenous and Topical Tranexamic Acid in Total Joint ArthroplastyOriginal papers

J. MASARYK1, V. MELUS2, J. VIDAN1, B. STENO3,*
1 Orthopaedic Department of the University Hospital Trencin, Trencin, Slovakia
2 Faculty of Health Care, Alexander Dubcek University of Trencin, Trencin, Slovakia
3 Second Department of Orthopaedics and Traumatology, University Hospital and Faculty of Medicine, Comenius University, Bratislava, Slovakia

PURPOSE OF THE STUDY:
To compare topical and intravenous (IV) administration of tranexamic acid (TXA) 2 g in patients undergoing total hip arthroplasty (THA), or total knee arthroplasty (TKA).

MATERIAL AND METHODS:
In total, 452 patients undergoing THA or TKA were randomised to 3 groups: 1) the IV TXA group received 2 doses of TXA 1 g intravenously 3 hours apart; 2) the topical TXA group received TXA 2 g topically, and 3) the NO TXA - control group. Furthermore, each group was divided in two subgroups by performed surgery (THA versus TKA). The following endpoints were used for final analysis: postoperative blood loss, transfusion requirement, haemoglobin drop and postoperative complications (haematoma, surgical site infection, thromboembolism, early surgical revision).

RESULTS:
Both topical and IV administration of TXA significantly reduced postoperative bleeding (mean ± standard deviation) after THA and TKA (topical 504.4±281.0 ml, IV 497.3±251.7 ml, NO 863.1±326.4 ml, p

Keywords: tranexamic acid, total hip arthroplasty, total knee arthroplasty, topical administration, intravenous administration

Published: August 15, 2022  Show citation

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MASARYK J, MELUS V, VIDAN J, STENO B. Comparison of Intravenous and Topical Tranexamic Acid in Total Joint Arthroplasty. Acta Chir Orthop Traumatol Cech. 2022;89(4):286-292. doi: 10.55095/achot2022/046. PubMed PMID: 36055669.
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